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KMID : 0357920010350040286
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Korean Journal of Pathology
2001 Volume.35 No. 4 p.286 ~ p.290
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Caspase 3 and Ki-67 Immunoreactivity and Its Correlation with Frequency of Apoptosis in Gastric Adenomas and Carcinomas
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Sohn Jin-Hee
Shin Hyung-Sik
Choi Kyung-Chan
Chae Seoung-Wan
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Abstract
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Background: Apoptosis, also known as programmed cell death, is under genetic control and is mediated by apoptosls-specific genes, cartain oncogenes and tumor suppressor genes. Caspase 3, a group of cystein proteases, is involved in the induction of apoptosis and has been considered to be correlated with apoptosis. Therefore, we tried to define whether caspase 3 is expressed in gastric adenoma and carcinoma, and correlated with apoptosis.
Methods: The apoptotic index and caspase 3 and Ki-67 immunoreactivity were observed in 25 gastric adenomas, 31 early gasfric carcinomas(EGC) and 64 advanced gastric carcinomas （AGC） by in situ labelling and immunohistochemistry.
Resulits: The mean number of apoptotic bodies and caspase 3 immunoreactivity were signifcantly increased from adenoma through EGC to AGC. Ki-67 immunoreactivity was more increased in AGC than in adenoma and EGC. And the number of apoptotic bodies were positively correlated with caspase 3 and Ki-67 immunoreactivity, and caspase 3 immunoreactivity was negatively correlated with Ki-67 immunoreactivity even though they were statistically insignificant.
Concluslons: Our results suggest that caspase 3 activation is important for inducing apopfosis, and both caspase 3 and apoptosis are increased along the tumor progression.
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KEYWORD
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Apoptosis, Caspases, Ki-67 antigen, Carcinoma, Stomach
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